Ann. Méd. Vét., 2010, 154 (1), pp 16-29 Staphylococcus aureus mastitis vaccination in dairy cattleWALLEMACQ H., GIRARD B., LEKEUX P., BUREAU F.Abstract :
Staphylococcus (S.) aureus is
a major pathogen for mastitis in dairy cattle. In most cases, S. aureus causes long-lasting subclinical and chronic bovine mastitis and leads to significant economic losses by reducing the quantity and the quality of the
milk produced. The pathogenesis of S. aureus mastitis includes the
ability to persist within host cells
and involves multiple virulence
factors including toxins, surface
proteins and polysaccharides.
The numerous vaccines that have been developed induce a specific immune response against these different factors.
These different vaccine approaches
are described and classified
depending on the target antigen used. Moreover, some recent vaccine strategies against human S. aureus infections are also discussed and could eventually be used for the design of new bovine vaccines. Although most of bovine vaccines induce
specific humoral response, to date, no vaccine has been described to protect efficiently against experimental and naturally occurred bovine S. aureus mastitis. In conclusion, this type of immune response and the broad antigenic variability of S. aureus strains can partially explain the lack of protection
observed during most of vaccine trials. Get the PDF Contact person : fabrice.bureau@ulg.ac.be |