Ann. Méd. Vét., 2008, 152 (2), pp 71-93 Actinobacillus pleuropneumoniae
virulence factors, the porcine pleuropneumonia etiologic agentVANDEN BERGH P., FETT T., ZECCHINON L., DESMECHT D.Abstract :
Porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae is a frequent and highly infectious disease generating significant economic losses related to deficiency in zootechnical profits and intensive use of antibiotics. This synthesis aims to review the bacterium elements necessary to pathogenesis development. At first time, we describe activation, secretion
and cytotoxic action of Apx toxins, recognized as A. pleuropneumoniae
major virulence factors.
Then, we develop the other ones which are the lipopolysaccharides, the polysaccharidic capsule, the fimbriae, iron and other nutrients capture systems, various proteases, installation of certain metabolic ways, flagella and the biofilm. Get the PDF Contact person : daniel.desmecht@ulg.ac.be |