Ann. Méd. Vét., 2007, 151 (1), pp 24-43 The role of synoviocytes in the inflamed diarthrodial joint.SCHNEIDER N., LEJEUNE J.P., DEBY-DUPONT G., SERTEYN D.Abstract :
The degenerative osteoarthritis is a common source of disease in the horse, causing pain and leading finally to the destruction of the cartilage in the diarthrodial joints. The synovial membrane
is a constitutive element of the joint, but often neglected due to its less obvious alterations, despite its crucial role.
This review of literature considers the embryology, the histology of synoviocytes in vivo and in vitro, gives information about the production of inflammatory
mediators, degrading enzymes, free oxygen radicals, about the composition of the synovial fluid and the interaction with chondrocytes.
The number of studies on equine synoviocytes in osteoarthritis is very restricted, therefore we included studies in other species and other types of joint
diseases to achieve a more complete image of the complex, interdependent and mutual acting mechanisms. Get the PDF Contact person : n.schneider@student.ulg.ac.be |