Ann. Méd. Vét., 2006, 150 (1), pp 27-42 Intracellular invasion of Staphylococcus aureus in nonphagocytic cellsBOULANGER D., BUREAU F., LEKEUX P.Abstract :
Staphylococcus aureus often causes chronic diseases. It is now believed that recurrence of these infections could be related to the ability of S. aureus to invade and persist within nonphagocytic cells. Adherence to eucaryotic cells is crucial for S. aureus to invade and persist within invasion and depends
on interactions between bacterial
fibronectin-binding proteins, fibronectin and the host cell fibronectin receptor, integrin α5β1. It is currently established that fibronectin acts as a bridging molecule. Penetration of S. aureus in host cells requires also activation of protein tyrosine kinases that mediate signal transduction and actin polymerization leading to cytoskeletal rearrangements. After internalization, S. aureus either remains in membrane-bound vacuoles or appears free in the cytoplasm.
After bacterial proliferation, S. aureus induces host cell apoptosis or persist inside cells as small colony variants, which represent a less virulent subpopulation of S. aureus that grows slower.
Although numerous in vitro and in vivo studies have demonstrated the ability of S. aureus to invade nonphagocytic cells, additional experiments have to be realized
to understand the relevance of intracellular localization in vivo. Get the PDF Contact person : delphine.boulanger@student.ulg.ac.be |